Hydrocortisone iv

Generic Name: hydrocortisone sodium succinate Dosage Form: injection, powder, for solution. Medically reviewed by Drugs. Last updated on Dec 1, Solu-Cortef Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. Solu-Cortef Sterile Powder is available in several packages for intravenous or intramuscular administration.

Vials containing hydrocortisone sodium succinate equivalent to mg hydrocortisone, 0. When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8. Hydrocortisone sodium succinate is a white or nearly white, odorless, hygroscopic amorphous solid. It is very soluble in water and in alcohol, very slightly soluble in acetone, and insoluble in chloroform. Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract.

Naturally occurring glucocorticoids hydrocortisone and cortisonewhich also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states.

Their synthetic analogs are primarily used for their anti-inflammatory effects in disorders of many organ systems. Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. The highly water-soluble sodium succinate ester of hydrocortisone permits the immediate intravenous administration of high doses of hydrocortisone in a small volume of diluent and is particularly useful where high blood levels of hydrocortisone are required rapidly.

Following the intravenous injection of hydrocortisone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. Excretion of the administered dose is nearly complete within 12 hours. Thus, if constantly high blood levels are required, injections should be made every 4 to 6 hours. This preparation is also rapidly absorbed when administered intramuscularly and is excreted in a pattern similar to that observed after intravenous injection.

Glucocorticoids cause profound and varied metabolic effects.

hydrocortisone iv

In addition, they modify the body's immune response to diverse stimuli. When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramuscular use of Solu-Cortef Sterile Powder is indicated as follows:. Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.

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Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme Stevens-Johnson syndrome. Primary or secondary adrenocortical insufficiency hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importancecongenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.

To tide the patient over a critical period of the disease in regional enteritis systemic therapy and ulcerative colitis. Acquired autoimmune hemolytic anemia, congenital erythroid hypoplastic anemia Diamond Blackfan anemiaidiopathic thrombocytopenic purpura in adults intravenous administration only; intramuscular administration is contraindicatedpure red cell aplasia, select cases of secondary thrombocytopenia.

Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy.

Sympathetic ophthalmia, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome, or that due to lupus erythematosus. Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.

As adjunctive therapy for short-term administration to tide the patient over an acute episode or exacerbation in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis selected cases may require low-dose maintenance therapy.

For the treatment of dermatomyositis, temporal arteritis, polymyositis, and systemic lupus erythematosus. Solu-Cortef Sterile Powder is contraindicated in systemic fungal infections and patients with known hypersensitivity to the product and its constituents. Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura.Enter your email address and we'll send you a link to reset your password.

These dose relationships only apply to oral or IV administration. Glucocorticoid potencies may differ greatly following intramuscular or intra-articular administration.

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Different glucocorticoids possess different duration of effect and potency; it is important to consider both factors when converting a steroid. Please fill out required fields. Remember to consider not just potency but also duration of effect. Dexamethasone typically requires much less frequent dosing due to its very long half-life and duration of action. This is an unprecedented time.

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OTC: Hydrocortisone

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Log in. Steroid Conversion Calculator Converts steroid dosages using dosing equivalencies.Medically reviewed by Drugs.

Hydrocortisone is a steroid medicine that is used in the treatment of many different conditions, including allergic disorders, skin conditions, ulcerative colitisarthritis, lupusmultiple sclerosisor lung disorders.

Hydrocortisone is also used to replace steroids in people with adrenal insufficiency decreased production of natural steroids by the adrenal glands. Hydrocortisone affects your immune system and is often used to treat certain blood cell disorders such as anemia low red blood cells or thrombocytopenia low platelets. Hydrocortisone is also used in the treatment of certain cancers such as leukemialymphoma, and multiple myeloma.

You should not use hydrocortisone if you are allergic to it, or if you have a fungal infection anywhere in your body. Steroids can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks. Long-term use of steroids may lead to bone loss osteoporosisespecially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis.

It is not known whether hydrocortisone will harm an unborn baby. However, using this medicine during pregnancy may cause a hormone deficiency in the newborn.

hydrocortisone iv

Tell your doctor if you are pregnant or plan to become pregnant. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you have trouble sleeping, you may need to take this medicine early in the day. Follow your doctor's dosing instructions very carefully. Your dose needs may change if you have a serious illness, fever or infection, surgery or a medical emergency.

Tell your doctor about any such situation that affects you. You should not stop taking hydrocortisone suddenly. Follow your doctor's instructions about tapering your dose. In case of emergency, wear or carry medical identification to let others know you use steroid medication. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.

Do not take two doses at one time. An overdose of hydrocortisone is not expected to produce life threatening symptoms. Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat especially in your face, neck, back, and waistincreased acne or facial hair, menstrual problems, impotenceor loss of interest in sex. Do not receive a "live" vaccine while using hydrocortisone. The vaccine may not work as well and may not fully protect you from disease.

Live vaccines include measles, mumps, rubella MMRpolio, rotavirus, typhoid, yellow fever, varicella chickenpoxand zoster shingles. Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles.Hydrocortisone has many uses in the treatment of cancer.

Hydrocortisone is used most often as a supportive care medication.

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Hydrocortisone is classified as a glucocorticosteroid. For more detail, see "How Hydrocortisone Works" section below. Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful. This list includes common and less common Hydrocortisone side effects. However, you should always inform your health care provider if you experience any unusual symptoms.

Contact your health care provider immediatelyday or night, if you should experience any of the following symptoms:.

hydrocortisone iv

The following symptoms require medical attention, but are not emergency situations. Contact your health care provider within 24 hours of noticing any of the following:. Always inform your health care provider if you experience any unusual symptoms. You will be checked regularly by your health care professional while you are taking Hydrocortisone, to monitor side effects and check your response to therapy.

Periodic blood work to monitor your complete blood count CBC as well as the function of other organs such as your kidneys and liver will also be ordered by your doctor. Corticosteroids are naturally produced by the adrenal gland in the body. Corticosteroids influence the functioning of most of the body's systems heart, immune, muscles and bones, endocrine and nervous system.

They exert a wide array of effects including effects on the metabolism of carbohydrates, protein and fats. They help to maintain balance of fluids and electrolytes. Hydrocortisone is classified as a corticosteroid more precisely a glucocorticosteroidand has many uses in the treatment of cancer.

One way that it works is to decrease inflammation swelling. It does this by preventing infection- fighting white blood cells polymorphonuclear leukocytes from traveling to the area of swelling in your body. This is why you are more prone to infection while taking steroids. Taking advantage of the anti-inflammatory properties of Hydrocortisone, corticosteroids are used to decrease the swelling around tumors. For example, by decreasing swelling around tumors in the spine, brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve pain or other symptoms caused by the pressing tumor.

Another way this drug works is by altering the body's normal immune system responses. In addition, it is thought that corticosteroids may help in the treatment of patients with blood disorders, such as multiple myeloma.

Corticosteroids may work by causing programmed cell death apoptosis of certain cells, which may help to fight your disease. Corticosteroids are also used in the short-term treatment of nausea caused by chemotherapy. How it does this is not fully understood. They also have been used to stimulate appetite for patients with severe appetite problems. Corticosteroids are used to replace steroids in conditions of adrenal insufficiency low production of needed steroids produced by the adrenal glands.Medically reviewed by Drugs.

Last updated on Jan 15, Suggested supplemental doses: -Illness with fever: Double fever greater than Dosing should be individualized on the basis of disease and patient response Oral: -Initial dose: 20 mg to mg orally per day Parenteral: -Initial dose: mg to mg IV or IM; may repeat doses at intervals of 2, 4, or 6 hours as indicated by response and clinical indication Maintenance dose: After a favorable initial response, dose should be decreased in small amounts to the lowest dose that maintains an adequate clinical response; if a positive response is not achieved after a reasonable period of time, alternative therapy should be sought.

Comments: -Lower doses, including doses lower than recommended doses, may suffice in less severe disease; doses in excess of recommended doses may be required in severe disease; in life-threatening situations, doses exceeding multiples of the oral dose may be justified. Uses: For use when oral therapy is not feasible; it is used as a potent anti-inflammatory agent in managing disorders, diseases, and conditions affecting many organ systems including endocrine, dermatologic, ophthalmic, nervous.

Use: To reduce risks of complications during and after surgery in patients with asthma. Use: As adjunctive therapy in the treatment of ulcerative colitis, especially distal forms. Use: As adjunctive therapy in the topical treatment of ulcerative proctitis of the distal portion of the rectum in patients who cannot retain hydrocortisone or other corticosteroid enemas.

Dosing should be individualized on the basis of disease and patient response -Initial dose: 0.

hydrocortisone iv

Uses: For use as a potent anti-inflammatory agent in managing disorders, diseases, and conditions affecting many organ systems including endocrine, dermatologic, ophthalmic, nervous, gastrointestinal, respiratory, musculoskeletal, and hematologic. Elderly: The serious consequences of corticosteroid side effects should be carefully considered when initiating therapy.

Hydrocortisone Dosage

Doses should be titrated based on patient response and severity of the condition; patients should be continuously monitored for signs that may require a dosage adjustment : -Increased doses may be needed during periods of stress e.

Gradual discontinuation of therapy is warranted if therapy is to be stopped after more than a few days. Approximate Equivalents IV or oral formulations : Hydrocortisone 20 mg is approximately equivalent to betamethasone 0.

Safety and efficacy of rectal products have not been established in patients younger than 18 years. Administration advice : Oral: Take with or after food to minimize stomach upset -For the treatment of primary adrenocortical insufficiency, first dose should be taken in the morning at awakening and the last dose approximately 4 to 6 hours before bed Parenteral: For IV or IM administration -IV: Administer over 30 seconds e.

Monitoring : -For patients with primary adrenal insufficiency, therapeutic monitoring should be based on clinical response rather than hormonal monitoring e. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information - verify here. Skip to Content. Hydrocortisone Dosage Medically reviewed by Drugs. Drug Status Rx. Availability Prescription only. Drug Class.

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Solu-Cortef

Hydrocortisone Images. Subscribe to our newsletters.Medically reviewed by Drugs. Last updated on Oct 19, Applies to hydrocortisone : oral tablet. Along with its needed effects, hydrocortisone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydrocortisone:. Some side effects of hydrocortisone may occur that usually do not need medical attention.

These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.

For Healthcare Professionals Applies to hydrocortisone: compounding powder, injectable powder for injection, injectable solution, injectable suspension, oral suspension, oral tablet, rectal foam with applicator, rectal suspension.

Frequency not reported : Bradycardiacardiac arrestcardia arrhythmias, cardiac enlargement, circulatory collapse, fat embolism, hypertension, congestive heart failurehypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, thrombophlebitis, vasculitissyncopetachycardiathromboembolismthrombophlebitis, vasculitis, necrotising angiitis [ Ref ]. Frequency not reported : Hypothalamus-pituitary-adrenal activity has been suppressed up to 12 months following long-term corticosteroid administration, Cushingoid appearance with chronic therapy, hirsutism, virilism, impotence, menstrual irregularities, hypertrichosis, moon face, latent hyperparathyroidism, hypoparathyroidism [ Ref ].

An antagonism occurs between the parathyroids and hypercorticism. Latent hyperparathyroidism may be unmasked by administration of corticosteroids; hypoparathyroidism may be manifest by phosphate retention occurring in renal failure caused by adrenal insufficiency.

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Frequency not reported : Gastrointestinal upset, nausea, vomiting, peptic ulcer disease, pancreatitisulcerative esophagitisabdominal distention, gastrointestinal perforation and hemorrhage, esophageal candidiasis [ Ref ]. Rare 0. Frequency not reported : Decreased glucose tolerance, hyperglycemia, hypokalemia, fluid retentionnegative nitrogen balance due to protein catabolism, increased blood urea nitrogen concentration, sodium retention, hypokalemic alkalosisincreased appetite, weight gain, hypertriglyceridemia [ Ref ].

Aseptic necrosis has been reported most often to affect the femoral head. Corticosteroid myopathy has presented as weakness and wasting of the proximal limb and girdle muscles and generally has been reversible following cessation of therapy. Corticosteroids inhibit intestinal absorption and increase urinary excretion of calcium leading to bone resorption and bone loss.

Postmenopausal females are at risk of loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures.

Frequency not reported : Steroid myopathy, muscle weakness, loss of muscle mass, osteoporosis, vertebral compression fractures, tendon rupture particularly the Achilles tendonaseptic necrosis of bone, growth suppression in pediatric patients, Charcot-like arthropathy, post-injection flare intra-articular useosteonecrosis [ Ref ]. Frequency not reported : Impairment in cell-mediated immunity, increased susceptibility to bacterial, viral, fungal and parasitic infections, immunosuppressionopportunistic infections from mild to fatal, reactivation of tuberculosis [ Ref ].

Increases in serum transaminases and alkaline phosphatase have been observed with corticosteroid therapy; these laboratory changes are generally small, not associated with clinical symptoms, and are reversible upon discontinuation. Frequency not reported : Reversible increases in serum transaminase and alkaline phosphatase concentrations, hepatomegaly [ Ref ]. Corticosteroid therapy has been associated with a total increase in WBC; with an increase in neutrophils and a decrease in monocytes, lymphocytes, and eosinophils.

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Frequency not reported : Leukocytosis [ Ref ]. Frequency not reported : Increased ease in bruising, ecchymosis, petechiaedelayed wound healing, acne, thin fragile skin, facial erythemaincreased sweating, suppress reaction to skin testing, allergic dermatitisburning or tingling in the perineal area after IV injection, cutaneous and subcutaneous atrophy, edemahyperpigmentation, hypopigmentation, erythema, sterile abscess, striae, thinning scalp hair, urticaria [ Ref ].

Frequency not reported : Increased intraocular pressure, glaucoma, posterior subcapsular cataracts, exophthalmos, central serous chorioretinopathy, corneal or scleral thinning, exacerbation of ophthalmic viral disease [ Ref ].

Psychological effects have been reported on withdrawal of corticosteroids, although the incidence is unknown. Frequency not reported : Psychoses, personality or behavioral changes, depression, emotional instability, euphoria, insomniamood swings, personality changes, psychic disorders, exacerbation of preexisting affect lability or psychotic behavior [ Ref ]. Case reports of hypersensitivity reactions to corticosteroids have been relatively uncommon.

Side effects have included bronchospasm, shock, urticaria, and angioedema. Cross-reactivity between aspirin and hydrocortisone in patients with aspirin-sensitive respiratory disease has been suggested as the mechanism in patients with asthmahowever data are controversial.

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Anaphylaxis has been most frequently associated with rapid injection or infusion of a high dose of corticosteroid. Reactions may be mediated by an immune or nonimmune mechanism.Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Side effects may include mood changes, increased risk of infectionand swelling. Hydrocortisone was patented in and approved for medical use in Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application.

It is used as an immunosuppressive druggiven by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedemain place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in patients on long-term steroid treatment to prevent an adrenal crisis. It may also be injected into inflamed joints resulting from diseases such as gout. Compared to hydrocortisone, prednisolone is about four times as strong and dexamethasone about forty times as strong in their anti-inflammatory effect.

It may be used topically for allergic rashes, eczemapsoriasisitching and other inflammatory skin conditions. Topical hydrocortisone creams and ointments are available in most countries without prescription in strengths ranging from 0. Covering the skin after application increases the absorption and effect.

Such enhancement is sometimes prescribed, but otherwise should be avoided to prevent overdose and systemic impact. A tube of hydrocortisone cream, purchased over the counter. Free cortisol passes easily through cellular membranes, where it binds to intracellular cortisol receptors. From Wikipedia, the free encyclopedia. AU : S4 Prescription only For oral use. S2 Pharmacy medicine for 0.

IUPAC name.

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Interactive image. American Society of Health-System Pharmacists. February 9, Archived from the original on 20 September Retrieved 30 August Principles and Practice of Endocrinology and Metabolism. Archived from the original on Retrieved 1 September Robin Analogue-based Drug Discovery.

World Health Organization model list of essential medicines: 21st list Geneva: World Health Organization. International Drug Price Indicator Guide. Retrieved 22 December Archived from the original on 21 June Retrieved 14 June Arquivos Brasileiros de Endocrinologia e Metabologia. Medical Physiology 2nd ed. Philadelphia: Saunders. Elks 14 November


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